Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27791609 | 0.86 | MAPT (0.42) | KMT2AMAPTLMNAUSP2TSHR | |
| SCHEMBL1735734 | 0.85 | MAPT (0.47) | KMT2AMAPTLMNAUSP2TSHR | |
| SCHEMBL1735736 | 0.85 | MAPT (0.47) | KMT2AMAPTLMNAUSP2TSHR | |
| SCHEMBL1735379 | 0.80 | USP2 (0.49) | KMT2AMAPTLMNAUSP2TSHR | |
| SCHEMBL1735375 | 0.80 | USP2 (0.49) | KMT2AMAPTLMNAUSP2TSHR | |
| SCHEMBL3626068 | 0.77 | USP2 (0.45) | KMT2AMAPTLMNAUSP2TSHR | |
| SCHEMBL1735652 | 0.75 | MAPT (0.50) | KMT2AMAPTLMNAUSP2TSHR | |
| SCHEMBL1735650 | 0.75 | MAPT (0.50) | KMT2AMAPTLMNAUSP2TSHR | |
| SCHEMBL3623767 | 0.72 | TSHR (0.44) | KMT2AMAPTLMNAUSP2TSHR | |
| SCHEMBL1735708 | 0.71 | MAPT (0.49) | KMT2AMAPTLMNAUSP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101641348-B | Imidazolidinone derivatives | HOFFMANN LA ROCHE | 2014-09-10 | — | — | CN | disclosed |
| CN-101641348-A | Imidazolidinone derivatives | HOFFMANN LA ROCHE CH | 2010-02-03 | — | — | CN | disclosed |