Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3630745 | 0.85 | MAPT (0.44) | TSHRLMNAMAPTHTTOPRK1 | |
| SCHEMBL1735652 | 0.82 | MAPT (0.50) | TSHRLMNAMAPTHTTTP53 | |
| SCHEMBL1735650 | 0.82 | MAPT (0.50) | TSHRLMNAMAPTHTTTP53 | |
| SCHEMBL1735379 | 0.81 | USP2 (0.49) | TSHRLMNAMAPTHTTTP53 | |
| SCHEMBL1735375 | 0.81 | USP2 (0.49) | TSHRLMNAMAPTHTTTP53 | |
| SCHEMBL27791609 | 0.81 | MAPT (0.42) | TSHRLMNAMAPTHTTOPRK1 | |
| SCHEMBL3626068 | 0.77 | USP2 (0.45) | TSHRLMNAMAPTHTTOPRK1 | |
| SCHEMBL1735710 | 0.76 | MAPT (0.49) | TSHRLMNAMAPTHTTTP53 | |
| SCHEMBL1735708 | 0.76 | MAPT (0.49) | TSHRLMNAMAPTHTTTP53 | |
| SCHEMBL1735736 | 0.76 | MAPT (0.47) | TSHRLMNAMAPTHTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142533-A1 | IMIDAZOLIDINONE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008119657-A1 | IMIDAZOLIDINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-09 | — | — | WO | disclosed |