Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1735652 | 0.86 | MAPT (0.50) | USP2MAPTSMN1; SMN2CYP2C9HPGD | |
| SCHEMBL1735650 | 0.86 | MAPT (0.50) | USP2MAPTSMN1; SMN2CYP2C9HPGD | |
| SCHEMBL3633776 | 0.85 | LMNA (0.48) | USP2MAPTSMN1; SMN2CYP2C9HPGD | |
| SCHEMBL27791609 | 0.79 | MAPT (0.42) | USP2MAPTSMN1; SMN2CYP2C9HPGD | |
| SCHEMBL1735708 | 0.78 | MAPT (0.49) | USP2MAPTSMN1; SMN2CYP2C9HPGD | |
| SCHEMBL1735710 | 0.78 | MAPT (0.49) | USP2MAPTSMN1; SMN2CYP2C9HPGD | |
| SCHEMBL1735379 | 0.78 | USP2 (0.49) | USP2MAPTSMN1; SMN2CYP2C9HPGD | |
| SCHEMBL1735375 | 0.78 | USP2 (0.49) | USP2MAPTSMN1; SMN2CYP2C9HPGD | |
| SCHEMBL27770391 | 0.77 | KMT2A (0.44) | USP2MAPTSMN1; SMN2CYP2C9HPGD | |
| SCHEMBL3623767 | 0.77 | TSHR (0.44) | USP2MAPTSMN1; SMN2CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142533-A1 | IMIDAZOLIDINONE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008119657-A1 | IMIDAZOLIDINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-09 | — | — | WO | disclosed |