Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2777130 | 0.81 | GAA (0.50) | ATMNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2777133 | 0.81 | GAA (0.50) | ATMNPC1RAB9AMEN1KMT2A | |
| SCHEMBL24060203 | 0.78 | ATM (0.68) | ATMNPC1RAB9AKMT2ALMNA | |
| SCHEMBL21362805 | 0.76 | ALDH1A1 (0.40) | ATMNPC1RAB9AMEN1KMT2A | |
| SCHEMBL6811236 | 0.76 | TRPA1 (0.49) | ATMNPC1RAB9AMEN1KMT2A | |
| SCHEMBL23958935 | 0.73 | MAOA (0.37) | NPC1RAB9ALMNAHTR7PTBP1 | |
| SCHEMBL12154075 | 0.73 | ALDH1A1 (0.38) | ATMNPC1RAB9AMEN1KMT2A | |
| SCHEMBL18809492 | 0.71 | LMNA (0.41) | LMNAHTR7PTBP1SMN1; SMN2POLB | |
| SCHEMBL23904715 | 0.71 | MAOA (0.38) | LMNAHTR7PTBP1SMN1; SMN2CES2 | |
| SCHEMBL23905645 | 0.71 | ALDH1A1 (0.39) | LMNAHTR7PTBP1SMN1; SMN2CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593102-B1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME (US) | 2017-06-07 | — | — | EP | disclosed |