Sugi Predict

Sugi Predict / Compounds / SCHEMBL277728

SCHEMBL277728

SCHEMBL277728

[O]c1ccn2ccccc12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALOX15 P16050 1/20 0.40
▸ KDM4E B2RXH2 3/20 0.32
▸ ALDH1A1 P00352 2/20 0.32
▸ GAA P10253 1/20 0.32
▸ HPGD P15428 1/20 0.32
▸ KLK7 P49862 1/20 0.32
▸ CHEK1 O14757 1/20 0.32
▸ FYN P06241 1/20 0.32
▸ PDGFRB P09619 1/20 0.32
▸ PIM1 P11309 1/20 0.32
▸ FGFR1 P11362 1/20 0.32
▸ GRK5 P34947 1/20 0.32
▸ KDR P35968 1/20 0.32
▸ MAP2K2 P36507 1/20 0.32
▸ MAPK8 P45983 1/20 0.32
▸ CDK8 P49336 1/20 0.32
▸ GSK3A P49840 1/20 0.32
▸ GSK3B P49841 1/20 0.32
▸ NEK2 P51955 1/20 0.32
▸ MAP2K1 Q02750 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL276893 0.84 KDM4E (0.39) ALOX15KDM4EALDH1A1GAAHPGD
SCHEMBL31609391 0.79 ALOX15 (0.43) ALOX15KDM4EALDH1A1GAAHPGD
SCHEMBL28939756 0.71 ALOX15 (0.37) ALOX15KDM4EALDH1A1GAAHPGD
SCHEMBL2005730 0.70 ALOX15 (0.40) ALOX15KDM4EALDH1A1GAAHPGD
SCHEMBL4397520 0.70 KDM4E (0.41) ALOX15KDM4EALDH1A1GAAHPGD
SCHEMBL10514874 0.70 ALOX15 (0.46) ALOX15KDM4EALDH1A1GAAHPGD
SCHEMBL16915952 0.70 ALOX15 (0.40) ALOX15KDM4EALDH1A1GAAHPGD
SCHEMBL2005732 0.70 ALOX15 (0.40) ALOX15KDM4EALDH1A1GAAHPGD
SCHEMBL28564397 0.70 ALOX15 (0.40) ALOX15KDM4EALDH1A1GAAHPGD
SCHEMBL28372316 0.70 ALOX15 (0.40) ALOX15KDM4EALDH1A1GAAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117835980-A Tetrahydropyrazolopyridine analog ligand of NLRX1 and application thereof 朗多生物制药股份有限公司 2024-04-05 — — CN disclosed
EP-4214200-A1 LANCL LIGANDS Nimmune Biopharma, Inc. (US) 2023-07-26 — — EP disclosed
CN-113748109-B Lanthionine C-like protein 2 ligands, cells prepared with said ligands and therapies using said ligands 朗多生物制药股份有限公司 2023-07-21 — — CN disclosed
WO-2023132369-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND HAVING NRF2 ACTIVATION EFFECT 中外製薬株式会社 2023-07-13 — — WO disclosed
CN-116368133-A NLRX1 ligand 朗多生物制药股份有限公司 2023-06-30 — — CN disclosed
US-20230167083-A1 LANCL LIGANDS LANDOS BIOPHARMA, INC. (US) 2023-06-01 — — US disclosed
CN-115485272-A PLXDC2 ligands 朗多生物制药股份有限公司 2022-12-16 — — CN disclosed
US-11459310-B2 LANCL ligands LANDOS BIOPHARMA, INC. (US) 2022-10-04 — — US disclosed
WO-2022087146-A1 LANCL LIGANDS LANDOS BIOPHARMA, INC. (US) 2022-04-28 — — WO disclosed
US-20220127250-A1 LANCL LIGANDS LANDOS BIOPHARMA, INC. (US) 2022-04-28 — — US disclosed
US-20060009439-A1 Novel physiologically active substances MERCIAN CORPORATION (JP) 2006-01-12 — — US disclosed
US-20050245514-A1 Novel physiologically active substances MICROBIOPHARM JAPAN CO., LTD. (JP) 2005-11-03 — — US disclosed
US-20050227959-A1 Heterocyclic compound having oxime group EISAI CO., LTD. (JP) 2005-10-13 — — US disclosed
EP-1548121-A1 NOVEL PHYSIOLOGICALLY ACTIVE SUBSTANCES MERCIAN CORPORATION (JP) 2005-06-29 — — EP disclosed
EP-1541570-A1 NOVEL PHYSIOLOGICALLY ACTIVE SUBSTANCE MERCIAN CORPORATION (JP) 2005-06-15 — — EP disclosed
EP-1508570-A1 NOVEL PHYSIOLGICALLY ACTIVE SUBSTANCES MERCIAN CORPORATION (JP) 2005-02-23 — — EP disclosed
WO-2004108683-A1 3-ALKYLIDENEHYDRAZINO SUBSTITUTED HETEROARYL COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2004-12-16 — — WO disclosed
EP-0483851-B1 Pyrazolyl acrylic acid derivatives, intermediates thereto, and agricultural/horticultural fungicides containing said derivatives MITSUBISHI CHEM CORP (JP) 1996-03-13 — — EP disclosed
US-5128350-A PYRAZOLYL ACRYLIC ACID DERIVATIVES AND AGRICULTURAL/HORTICULTURAL FUNGICIDES CONTAINING SAID DERIVATIVES MITSUBISHI KASEI CORPORATION (JP) 1992-07-07 — — US disclosed
EP-0483851-A1 Pyrazolyl acrylic acid derivatives, intermediates thereto, and agricultural/horticultural fungicides containing said derivatives Mitsubishi Chemical Corporation (JP) 1992-05-06 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050245514-A1 Novel physiologically active substances HIF1A, HIF1AN, VEGFA ALOX15 3033/4885KDM4E 4239/4885ALDH1A1 133/4885
US-20220127250-A1 LANCL LIGANDS LANCL2, LANCL1, LCLAT1 ALOX15 1739/4885KDM4E 3554/4885ALDH1A1 4156/4885
US-20060009439-A1 Novel physiologically active substances HIF1A, HIF1AN, VEGFA ALOX15 2079/4885KDM4E 3533/4885ALDH1A1 108/4885
US-11459310-B2 LANCL ligands LANCL2, LANCL1, ACSL1 ALOX15 1177/4885KDM4E 3796/4885ALDH1A1 3541/4885
US-20050227959-A1 Heterocyclic compound having oxime group STAT6, HRH4, HRH2 ALOX15 283/4885KDM4E 855/4885ALDH1A1 1391/4885
US-20230167083-A1 LANCL LIGANDS LANCL2, LANCL1, LCLAT1 ALOX15 1739/4885KDM4E 3554/4885ALDH1A1 4156/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.