Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 11/20 | 0.51 |
| ▸ | NFATC1 | O95644 | 6/20 | 0.51 |
| ▸ | GSK3B | P49841 | 4/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.43 |
| ▸ | CDK9 | P50750 | 2/20 | 0.43 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2268299 | 0.81 | CCNT1 (0.62) | DYRK1ANFATC1GSK3BCDK2DYRK1B | |
| SCHEMBL29664462 | 0.81 | CCNT1 (0.62) | DYRK1ANFATC1GSK3BCDK2DYRK1B | |
| Hydrochloric Acid SCHEMBL3831446 | 0.80 | CCNT1 (0.60) | DYRK1ANFATC1GSK3BCDK2DYRK1B | |
| SCHEMBL4268142 | 0.77 | CCNT1 (0.65) | DYRK1ANFATC1GSK3BCDK2DYRK1B | |
| SCHEMBL4268145 | 0.77 | CCNT1 (0.65) | DYRK1ANFATC1GSK3BCDK2DYRK1B | |
| SCHEMBL2619228 | 0.75 | DYRK1A (0.56) | DYRK1ANFATC1GSK3BCDK2DYRK1B | |
| SCHEMBL6753342 | 0.74 | APP (0.63) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL315329 | 0.72 | CYP2A6 (0.64) | KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL18746021 | 0.71 | DYRK1A (0.56) | DYRK1ANFATC1GSK3BCDK2DYRK1B | |
| SCHEMBL245511 | 0.71 | DYRK1A (0.61) | DYRK1ANFATC1GSK3BCDK2DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101646656-B | Pyrimidine hydrazide compounds as PGDS inhibitors | SANOFI AVENTIS SPA | 2013-08-14 | — | — | CN | disclosed |
| CN-101646656-A | Pyrimidine hydrazide compounds as the PGDS inhibitor | SANOFI AVENTIS FR | 2010-02-10 | — | — | CN | disclosed |