Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4436306 | 0.91 | MAPK1 (0.55) | MAPK1ALDH1A1L3MBTL1LMNAMAPT | |
| SCHEMBL27775574 | 0.90 | MAPT (0.48) | MAPK1ALDH1A1L3MBTL1LMNAMAPT | |
| SCHEMBL27776006 | 0.88 | MAPT (0.52) | MAPK1ALDH1A1L3MBTL1LMNAMAPT | |
| SCHEMBL27775683 | 0.87 | LMNA (0.61) | MAPK1ALDH1A1L3MBTL1LMNAMAPT | |
| SCHEMBL28782667 | 0.87 | ALDH1A1 (0.51) | MAPK1ALDH1A1L3MBTL1LMNAMAPT | |
| SCHEMBL28782595 | 0.86 | POLB (0.48) | MAPK1ALDH1A1L3MBTL1LMNAMAPT | |
| SCHEMBL27775873 | 0.86 | POLB (0.50) | MAPK1ALDH1A1L3MBTL1LMNAMAPT | |
| SCHEMBL28782616 | 0.85 | KDM4E (0.45) | ALDH1A1L3MBTL1LMNAMAPTKDM4E | |
| SCHEMBL27775746 | 0.84 | MAPT (0.44) | MAPK1ALDH1A1L3MBTL1LMNAMAPT | |
| SCHEMBL27929712 | 0.83 | MAPT (0.46) | MAPK1ALDH1A1L3MBTL1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101679266-B | PIM kinase inhibitors and methods of their use | NOVARTIS AG | 2015-05-06 | — | — | CN | disclosed |
| CN-101679266-A | PIM kinase inhibitors and methods of their use | NOVARTIS AG | 2010-03-24 | — | — | CN | disclosed |