Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27775556 | 0.90 | ALDH1A1 (0.45) | MAOBALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL28274463 | 0.78 | ALDH1A1 (0.42) | ALDH1A1KDM4ESMN1; SMN2MAPTMAPK1 | |
| SCHEMBL27685360 | 0.78 | PTPN1 (0.39) | — | |
| SCHEMBL27794009 | 0.77 | HRH3 (0.45) | ALDH1A1KDM4ELMNARAB9ACYP2C19 | |
| SCHEMBL27717446 | 0.76 | KDM4E (0.39) | ALDH1A1KDM4ENPC1RAB9AALOX15 | |
| SCHEMBL27459025 | 0.76 | HPGD (0.33) | ALDH1A1MAPTHPGD | |
| SCHEMBL28785094 | 0.73 | ALDH1A1 (0.38) | MAOBALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL27711108 | 0.73 | PARP1 (0.45) | PARP1 | |
| SCHEMBL28788261 | 0.72 | TSHR (0.36) | MAOBALDH1A1NPC1LMNAMAPT | |
| SCHEMBL9356659 | 0.69 | ALPG (0.70) | ALDH1A1KDM4ECNR2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101679401-B | 2-oxo-3-benzyl-benzoxazol-2-one derivatives and related compounds as MET kinase inhibitors for the treatment of tumors | MERCK PATENT GMBH | 2012-12-12 | — | — | CN | disclosed |
| CN-101679401-A | 2-oxo-3-benzyl-benzoxazol-2-one derivatives and related compounds as MET kinase inhibitors for the treatment of tumors | MERCK PATENT GMBH | 2010-03-24 | — | — | CN | disclosed |