SCHEMBL27775950

SCHEMBL27775950

COc1c(O)c2c(c(OC)c1OC)OC(c1cc(O)ccc1O)C(=O)C2

nearest known ligand 0.35

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.35
HPGD P15428 2/20 0.35
MAPT P10636 1/20 0.35
PPARG P37231 1/20 0.33
PTPN1 P18031 1/20 0.33
TAS2R31 P59538 1/20 0.33
RECQL P46063 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
MAOB P27338 2/20 0.32
MAOA P21397 1/20 0.32
IDO1 P14902 1/20 0.32
KDM4E B2RXH2 1/20 0.32
GLA P06280 1/20 0.32
GAA P10253 1/20 0.32
ACHE P22303 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4226006 0.82 TAS2R31 (0.45) ALDH1A1HPGDMAPTPTPN1TAS2R31
SCHEMBL4129050 0.77 CDK1 (0.47) ALDH1A1MAPTTAS2R31KDM4EGAA
SCHEMBL27950799 0.72 TAS2R31 (0.39) ALDH1A1MAPTPTPN1TAS2R31TDP1
SCHEMBL27775946 0.72 IDO1 (0.49) ALDH1A1MAPTTAS2R31TDP1IDO1
SCHEMBL29204371 0.71 CYP19A1 (0.42) MAPTRECQLKDM4EGAA
SCHEMBL27775453 0.69 NPC1 (0.44) ALDH1A1HPGDMAPTPTPN1TAS2R31
SCHEMBL17503283 0.68 NPC1 (0.45) ALDH1A1MAPTRECQLGAA
SCHEMBL28085134 0.66 CDK1 (0.45) GAAACHE
SCHEMBL4225998 0.66 PTPN1 (0.47) MAPTPTPN1RECQLKDM4EGAA
SCHEMBL28840935 0.66 CYP19A1 (0.46) MAPTRECQLKDM4EGAAACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101615222-A A kind of Chinese prescription designing technique based on the Chinese medicine effective component group INST OF RADIATION MEDICINE CHI 2009-12-30 CN disclosed