Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PYGL | P06737 | 5/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27755234 | 0.84 | NPC1 (0.39) | HPGDRAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL27775828 | 0.80 | KMT2A (0.40) | RAB9ANPC1P2RX7KMT2AMAPT | |
| SCHEMBL27755244 | 0.78 | ERCC5 (0.47) | HPGDRAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL27775801 | 0.77 | KCNK3 (0.37) | RAB9ANPC1KMT2AMAPT | |
| SCHEMBL1549680 | 0.77 | PYGL (0.44) | HPGDRAB9ANPC1P2RX7MAPK1 | |
| SCHEMBL1549681 | 0.76 | KMT2A (0.42) | HPGDRAB9ANPC1P2RX7MAPK1 | |
| SCHEMBL9423079 | 0.76 | HPGD (0.49) | HPGDRAB9ANPC1P2RX7MAPK1 | |
| SCHEMBL27776199 | 0.75 | FLT1 (0.43) | HPGDRAB9ANPC1MAPK1KMT2A | |
| SCHEMBL27776094 | 0.74 | NPC1 (0.48) | RAB9ANPC1MAPK1L3MBTL1MAPT | |
| SCHEMBL18451321 | 0.74 | HPGD (0.50) | HPGDRAB9ANPC1P2RX7MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102089287-B | Tetrahydrocinnolines as 11 beta HSD1 inhibitors for diabetes | HOFFMANN LA ROCHE | 2013-10-23 | — | — | CN | disclosed |
| CN-102089287-A | Tetrahydrocinnolines as 11 beta HSD1 inhibitors for diabetes | HOFFMANN LA ROCHE | 2011-06-08 | — | — | CN | disclosed |
| CN-101528713-A | Pyridazine derivatives as inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 | HOFFMANN LA ROCHE (CH) | 2009-09-09 | — | — | CN | disclosed |