Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27957016 | 0.92 | SCD (0.48) | SCDALDH1A1PKMP2RX7KDM4E | |
| SCHEMBL27756654 | 0.91 | SCD (0.49) | SCD | |
| SCHEMBL27756798 | 0.89 | SCD (0.38) | SCDALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL27756666 | 0.88 | SCD (0.51) | SCDALDH1A1PKMCYP2C19MAPT | |
| SCHEMBL27777551 | 0.87 | ALDH1A1 (0.37) | SCDALDH1A1PKMMAPTKDM4E | |
| SCHEMBL27777537 | 0.86 | SCD (0.37) | SCDALDH1A1PKMCYP3A4CYP2C9 | |
| SCHEMBL27777545 | 0.85 | SCD (0.47) | SCDALDH1A1PKMCYP3A4CYP2C9 | |
| SCHEMBL27855677 | 0.85 | SCD (0.43) | SCD | |
| SCHEMBL27838041 | 0.84 | SCD (0.48) | SCDALDH1A1KDM4E | |
| SCHEMBL27855718 | 0.84 | SCD (0.42) | SCDALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101535303-A | Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid level | NOVARTIS AG (CH) | 2009-09-16 | — | — | CN | claimed |
| CN-101535303-B | Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid level | NOVARTIS AG | 2012-07-18 | — | — | CN | disclosed |
| CN-101535303-A | Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid level | NOVARTIS AG (CH) | 2009-09-16 | — | — | CN | disclosed |