Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14127344 | 0.78 | SMN1; SMN2 (0.42) | SMN1; SMN2CYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL28000938 | 0.78 | SMN1; SMN2 (0.42) | SMN1; SMN2CYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL27707801 | 0.77 | EDNRA (0.31) | — | |
| SCHEMBL27624331 | 0.75 | CYP3A4 (0.43) | SMN1; SMN2MAPTCYP3A4CYP2D6SLC6A2 | |
| SCHEMBL27656284 | 0.75 | CYP3A4 (0.43) | SMN1; SMN2MAPTCYP3A4CYP2D6SLC6A2 | |
| SCHEMBL1554283 | 0.74 | MAPT (0.39) | SMN1; SMN2MAPTCHRNB2CHRNA3CHRNA7 | |
| SCHEMBL1993051 | 0.73 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPTCHRNB2CHRNA3CHRNA7 | |
| SCHEMBL1090665 | 0.73 | SMN1; SMN2 (0.44) | SMN1; SMN2CYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL753852 | 0.72 | NAPRT (0.44) | SMN1; SMN2MAPTCYP3A4CYP2D6SLC6A2 | |
| SCHEMBL890206 | 0.72 | ALDH1A1 (0.41) | SMN1; SMN2MAPTCYP3A4CYP2D6SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541785-B | Substituted dihydropyrazolones and use thereof as HIF-prolyl-4 -hydroxylase inhibitors | BAYER IP GMBH | 2014-03-12 | — | — | CN | disclosed |
| CN-101541785-A | Substituted dihydropyrazolones and use thereof as HIF-prolyl-4 -hydroxylase inhibitors | BAYER SCHERING PHARMA AG (DE) | 2009-09-23 | — | — | CN | disclosed |