Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 4/20 | 0.42 |
| ▸ | QPCT | Q16769 | 1/20 | 0.41 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7232205 | 0.81 | METAP2 (0.49) | ALDH1A1MKNK1MKNK2FGFR1MAPT | |
| SCHEMBL5687618 | 0.79 | MKNK1 (0.45) | ALDH1A1MKNK1MKNK2IDO1ESR2 | |
| SCHEMBL4446246 | 0.78 | CYP2A6 (0.47) | HPGDALDH1A1BCL2L1HSD17B10KDM1A | |
| SCHEMBL27783776 | 0.78 | KDM1A (0.49) | HPGDALDH1A1BCL2L1HSD17B10KDM1A | |
| SCHEMBL8446312 | 0.76 | MKNK1 (0.46) | MKNK1MKNK2 | |
| SCHEMBL29434894 | 0.75 | ALDH1A1 (0.58) | HPGDALDH1A1BCL2L1HSD17B10NPC1 | |
| SCHEMBL7110132 | 0.75 | ALDH1A1 (0.58) | HPGDALDH1A1BCL2L1HSD17B10NPC1 | |
| SCHEMBL5700123 | 0.74 | MKNK1 (0.55) | ALDH1A1MKNK1MKNK2FGFR1NPSR1 | |
| SCHEMBL28988268 | 0.74 | ALDH1A1 (0.50) | HPGDALDH1A1BCL2L1HSD17B10KMT2A | |
| SCHEMBL10356483 | 0.74 | ALDH1A1 (0.56) | HPGDALDH1A1BCL2L1HSD17B10KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110177786-A | Pyrazolo [1,5-A] pyridine compounds being substituted are as RET kinase inhibitor | 阿雷生物药品公司 | 2019-08-27 | — | — | CN | disclosed |
| CN-101553233-B | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases | DECIPHERA PHARMACEUTICALS LLC | 2013-05-29 | — | — | CN | disclosed |
| CN-101553233-A | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases | DECIPHERA PHARMACEUTICALS LLC (US) | 2009-10-07 | — | — | CN | disclosed |