Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 3/20 | 0.38 |
| ▸ | SRC | P12931 | 3/20 | 0.37 |
| ▸ | LYN | P07948 | 2/20 | 0.37 |
| ▸ | CDK4 | P11802 | 3/20 | 0.37 |
| ▸ | CCND1 | P24385 | 3/20 | 0.37 |
| ▸ | CCND2 | P30279 | 3/20 | 0.37 |
| ▸ | CCND3 | P30281 | 3/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27780893 | 0.88 | PLK1 (0.43) | PLK1HTR2AHTR2CALDH1A1MAPT | |
| SCHEMBL29093852 | 0.83 | HTR2A (0.35) | HTR2AHTR2CMAPTBTKSRC | |
| SCHEMBL29093832 | 0.81 | HTR2A (0.34) | HTR2AHTR2CALDH1A1MAPTBTK | |
| SCHEMBL28779597 | 0.78 | HDAC1 (0.43) | PLK1HTR2AHTR2CALDH1A1MAPT | |
| SCHEMBL9540156 | 0.78 | POLB (0.45) | ALDH1A1MAPTCDK4CCND1CCND2 | |
| SCHEMBL27780822 | 0.76 | KCNH2 (0.39) | DRD2SLC6A4 | |
| SCHEMBL28799118 | 0.74 | HTR2A (0.36) | HTR2AHTR2CALDH1A1MAPTBTK | |
| SCHEMBL14155061 | 0.72 | HTR2A (0.61) | HTR2AHTR2CCYP11B1CYP11B2 | |
| SCHEMBL29094005 | 0.71 | HTR2A (0.35) | PLK1HTR2AHTR2CALDH1A1MAPT | |
| SCHEMBL12466580 | 0.71 | CCR2 (0.57) | ALDH1A1MAPTPTGDR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101516889-B | Derivatives and analogs of n-ethylquinolones and n-ethylazaquinolones | GLAXO GROUP LTD | 2013-07-31 | — | — | CN | disclosed |
| CN-101516889-A | Derivatives and analogs of n-ethylquinolones and n-ethylazaquinolones | GLAXO GROUP LTD (GB) | 2009-08-26 | — | — | CN | disclosed |