Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 2/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | ADA | P00813 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29215894 | 1.00 | KDM5A (0.46) | KDM5AKDM4CKDM5BADAKDM4E | |
| SCHEMBL29215817 | 1.00 | KDM5A (0.46) | KDM5AKDM4CKDM5BADAKDM4E | |
| SCHEMBL29663447 | 0.88 | ADA (0.47) | KDM5AKDM4CKDM5BADAKDM4E | |
| SCHEMBL29663112 | 0.88 | ADA (0.47) | KDM5AKDM4CKDM5BADAKDM4E | |
| SCHEMBL18040235 | 0.88 | ADA (0.47) | KDM5AKDM4CKDM5BADAKDM4E | |
| SCHEMBL30291411 | 0.85 | KDM5A (0.39) | KDM5AKDM4CKDM5BADAKDM4E | |
| SCHEMBL27781574 | 0.85 | ADA (0.51) | KDM5AADA | |
| SCHEMBL29910466 | 0.85 | KDM5A (0.39) | KDM5AKDM4CKDM5BADAKDM4E | |
| SCHEMBL28934818 | 0.84 | ADA (0.43) | KDM4CADAKDM4E | |
| SCHEMBL710186 | 0.82 | KDM5A (0.48) | KDM5AADAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115461338-B | 3-azabicyclo (3.1.0) hexane derivatives having KDM5 inhibitory activity and uses thereof | 小野药品工业株式会社 | 2024-02-20 | — | — | CN | disclosed |
| CN-101679293-A | Urocanic acid derivatives useful for the treatment of immune-related and inflammatory diseases | VALETTA HEALTH B V | 2010-03-24 | — | — | CN | disclosed |