Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADA | P00813 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29215817 | 0.84 | KDM5A (0.46) | ADAKDM4EKDM4C | |
| SCHEMBL29215894 | 0.84 | KDM5A (0.46) | ADAKDM4EKDM4C | |
| SCHEMBL27781647 | 0.84 | KDM5A (0.46) | ADAKDM4EKDM4C | |
| SCHEMBL4981212 | 0.84 | ADA (0.55) | ADA | |
| SCHEMBL28934757 | 0.80 | NOTUM (0.48) | ADAKDM4E | |
| SCHEMBL710186 | 0.79 | KDM5A (0.48) | ADAKDM4E | |
| SCHEMBL18040235 | 0.79 | ADA (0.47) | ADAKDM4EKDM4C | |
| SCHEMBL29663447 | 0.79 | ADA (0.47) | ADAKDM4EKDM4C | |
| SCHEMBL29663112 | 0.79 | ADA (0.47) | ADAKDM4EKDM4C | |
| Hydrochloric Acid SCHEMBL29910419 | 0.78 | KDM5A (0.47) | ADAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115461338-B | 3-azabicyclo (3.1.0) hexane derivatives having KDM5 inhibitory activity and uses thereof | 小野药品工业株式会社 | 2024-02-20 | — | — | CN | disclosed |
| EP-4146645-A1 | 3-AZABICYCLO(3.1.0)HEXANE DERIVATIVES HAVING KDM5 INHIBITORY ACTIVITY AND USE THEREOF | ONO Pharmaceutical Co., Ltd. (JP) | 2023-03-15 | — | — | EP | disclosed |
| CN-115461338-A | 3-azabicyclo (3.1.0) hexane derivatives having KDM5 inhibitory activity and uses thereof | 小野药品工业株式会社 | 2022-12-09 | — | — | CN | disclosed |