Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28784048 | 0.91 | LRRK2 (0.37) | LRRK2DYRK1BPRKCISTK3BRD4 | |
| SCHEMBL858348 | 0.85 | MAPK8 (0.51) | LRRK2DYRK1BCDC7PLK4CHEK1 | |
| SCHEMBL858144 | 0.83 | LRRK2 (0.46) | LRRK2DYRK1BCDC7PLK4CHEK1 | |
| SCHEMBL858159 | 0.79 | HSD17B10 (0.46) | LRRK2DYRK1BROCK2ROCK1CDC42BPA | |
| SCHEMBL858955 | 0.78 | PRKAG1 (0.43) | AXLCLK2RPS6KA3PRKAA1MKNK2 | |
| SCHEMBL858863 | 0.77 | PRKCI (0.49) | LRRK2DYRK1BCDC7PLK4CHEK1 | |
| SCHEMBL857795 | 0.77 | LRRK2 (0.48) | LRRK2DYRK1BCDK1CDK2AXL | |
| SCHEMBL878866 | 0.74 | USP2 (0.50) | LRRK2SYKMELKSMN1; SMN2MAPT | |
| SCHEMBL857913 | 0.74 | CAMKK2 (0.40) | LRRK2ROCK2SYKNPC1CAMKK2 | |
| SCHEMBL858970 | 0.73 | CHUK (0.44) | LRRK2CDK2MAPK8GSK3BROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1925855-B | Compounds and methods for development of Ret modulators | PLEXXIKON INC | 2010-06-16 | — | — | CN | claimed |