Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | PDE9A | O76083 | 1/20 | 0.59 |
| ▸ | ESR1 | P03372 | 3/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | FRK | P42685 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1239816 | 0.86 | MAPT (0.65) | MAPTPDE9AESR1ESR2KDM4E | |
| SCHEMBL28132803 | 0.83 | MAPT (0.71) | MAPTPDE9AESR1ESR2KDM4E | |
| SCHEMBL5528637 | 0.79 | KDM4E (0.59) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL29709937 | 0.79 | MAPT (0.75) | MAPTPDE9AESR1ESR2KDM4E | |
| SCHEMBL5396117 | 0.79 | MAPT (0.75) | MAPTPDE9AESR1ESR2KDM4E | |
| SCHEMBL27785106 | 0.79 | MAPT (0.60) | MAPTPDE9AESR1ESR2KDM4E | |
| SCHEMBL27783904 | 0.79 | MAPT (0.60) | MAPTPDE9AESR1ESR2KDM4E | |
| SCHEMBL8987076 | 0.79 | MAPT (0.60) | MAPTPDE9AESR1ESR2KDM4E | |
| SCHEMBL31179077 | 0.79 | MAPK1 (0.68) | MAPTPDE9AESR1ESR2KDM4E | |
| SCHEMBL6545945 | 0.79 | MAPK1 (0.68) | MAPTPDE9AESR1ESR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101747267-B | Method for synthesizing 4-substituted-3-chlorine-2-carbostyril | UNIV SOUTHWEST | 2011-07-13 | — | — | CN | claimed |
| CN-101747267-A | Method for synthesizing 4-substituted-3-chlorine-2-carbostyril | UNIV SOUTHWEST | 2010-06-23 | — | — | CN | claimed |
| CN-101747267-B | Method for synthesizing 4-substituted-3-chlorine-2-carbostyril | UNIV SOUTHWEST | 2011-07-13 | — | — | CN | disclosed |
| CN-101747267-A | Method for synthesizing 4-substituted-3-chlorine-2-carbostyril | UNIV SOUTHWEST | 2010-06-23 | — | — | CN | disclosed |