Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 14/20 | 0.33 |
| ▸ | F2R | P25116 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27804752 | 0.80 | NPC1 (0.33) | — | |
| SCHEMBL27783222 | 0.74 | — | — | |
| SCHEMBL430916 | 0.74 | MAPKAPK2 (0.44) | MAPKAPK2HPGDSGRM5F2RCYP1A2 | |
| SCHEMBL13958006 | 0.69 | MAPKAPK2 (0.44) | MAPKAPK2HPGDSGRM5F2RCYP1A2 | |
| SCHEMBL27921502 | 0.64 | HTR2C (0.41) | — | |
| SCHEMBL4430650 | 0.61 | MAP4K4 (0.46) | HPGDSGRM5 | |
| SCHEMBL27095783 | 0.60 | TAAR1 (0.56) | HPGDS | |
| SCHEMBL28856766 | 0.60 | CYP1A2 (0.58) | HPGDSGRM5CYP1A2 | |
| SCHEMBL31325780 | 0.60 | CYP1A2 (0.58) | HPGDSGRM5CYP1A2 | |
| SCHEMBL14983675 | 0.60 | HPGDS (0.46) | HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101687869-A | Tetracyclic lactam derivatives as MK2 inhibitors | NOVARTIS AG | 2010-03-31 | — | — | CN | disclosed |