Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 4/20 | 0.46 |
| ▸ | HPGDS | O60760 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13690045 | 0.72 | HPGDS (0.70) | MAP4K4HPGDSCHEK1CHEK2CDC7 | |
| SCHEMBL22573442 | 0.70 | MAP4K4 (0.51) | MAP4K4HPGDSCHEK2CSNK1D | |
| SCHEMBL1365691 | 0.69 | MAP4K4 (0.59) | MAP4K4HPGDSCHEK1GRM5 | |
| SCHEMBL31324955 | 0.69 | KMO (0.48) | MAP4K4HPGDSCSNK1D | |
| SCHEMBL3213900 | 0.68 | HPGDS (0.54) | HPGDSCSNK1D | |
| SCHEMBL22573742 | 0.68 | MEN1 (0.48) | MAP4K4HPGDS | |
| Hydrochloric Acid SCHEMBL3222314 | 0.67 | HPGDS (0.53) | HPGDSCSNK1D | |
| SCHEMBL3820128 | 0.67 | MAP4K4 (0.53) | MAP4K4HPGDSCHEK1CHEK2SYK | |
| SCHEMBL3222305 | 0.67 | HPGDS (0.53) | MAP4K4HPGDSCHEK2CSNK1D | |
| SCHEMBL22573465 | 0.67 | HPGDS (0.51) | MAP4K4HPGDSCHEK2JAK2CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132196-A1 | NICOTINAMIDE DERIVATIVES AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES | Pfizer Products Inc. (US) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008104869-A1 | NICOTINAMIDE DERIVATIVES AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES | PFIZER PRODUCTS INC. (US) | 2008-09-04 | — | — | WO | disclosed |