Questiomycin B

Questiomycin B

SCHEMBL2778643

CCOc1ccccc1N.Nc1ccccc1O

nearest known ligand 0.78

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.78
TSHR P16473 2/20 0.56
ALOX15 P16050 1/20 0.56
CYP1A2 P05177 1/20 0.55
CYP2C9 P11712 1/20 0.55
CYP2C19 P33261 1/20 0.55
MAPT P10636 5/20 0.47
L3MBTL1 Q9Y468 4/20 0.47
MAPK1 P28482 2/20 0.47
HSD17B10 Q99714 2/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
KDM4E B2RXH2 1/20 0.47
POLB P06746 1/20 0.47
HPGD P15428 1/20 0.47
GAA P10253 3/20 0.45
TDP1 Q9NUW8 3/20 0.45
ADRA2B P18089 1/20 0.45
PTGS1 P23219 1/20 0.45
NPC1 O15118 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alcohol SCHEMBL29138983 0.88 ALDH1A1 (0.91) ALDH1A1CYP1A2CYP2C9CYP2C19MAPT
SCHEMBL15704 0.88 ALDH1A1 (1.00) ALDH1A1ALOX15CYP1A2CYP2C9CYP2C19
SCHEMBL29466998 0.88 ALDH1A1 (1.00) ALDH1A1ALOX15CYP1A2CYP2C9CYP2C19
Hydrochloric Acid SCHEMBL4379595 0.86 ALDH1A1 (0.95) ALDH1A1CYP1A2CYP2C9CYP2C19MAPT
Hydrochloric Acid SCHEMBL2862605 0.86 ALDH1A1 (0.95) ALDH1A1CYP1A2CYP2C9CYP2C19MAPT
Ammonia Solution, Strong SCHEMBL7607913 0.86 ALDH1A1 (0.95) ALDH1A1ALOX15CYP1A2CYP2C9CYP2C19
Propanol SCHEMBL6496776 0.83 ALDH1A1 (0.81) ALDH1A1CYP1A2CYP2C9CYP2C19MAPT
Cyanide SCHEMBL28071429 0.82 ALDH1A1 (0.88) ALDH1A1ALOX15CYP1A2CYP2C9CYP2C19
Questiomycin B SCHEMBL27305569 0.82 ALOX15 (0.75) ALDH1A1TSHRALOX15CYP1A2CYP2C9
Acetic Acid SCHEMBL29168779 0.81 ALDH1A1 (0.78) ALDH1A1CYP1A2CYP2C9CYP2C19MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2181985-A1 Antiviral Agent SHIONOGI & CO., LTD. (JP) 2010-05-05 EP disclosed
CN-100491349-C Antiviral agent SHIONOGI & CO (JP) 2009-05-27 CN disclosed
CN-1558898-A Antiviral agent ��Ұ����ҩ��ʽ���� 2004-12-29 CN disclosed