Pyrimidine

Pyrimidine

SCHEMBL27787016

CN.CN.CN.c1cncnc1

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.40
NAPRT Q6XQN6 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
CYP2A6 P11509 1/20 0.35
HSP90AA1 P07900 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyrimidine SCHEMBL27480983 1.00
Pyrimidine SCHEMBL10847950 0.96
Pyrimidine SCHEMBL27755630 0.87
Pyrimidine SCHEMBL6837713 0.87
Pyrimidine SCHEMBL10646 0.87 TSHR (0.50) TSHRNAPRTTDP1CYP2A6HSP90AA1
Pyrimidine SCHEMBL1846 0.87
Pyrimidine SCHEMBL19437633 0.87 TSHR (0.50) TSHRNAPRTTDP1CYP2A6HSP90AA1
Pyrimidine SCHEMBL28362645 0.83
Pyrimidine SCHEMBL4422279 0.83
Pyrimidine SCHEMBL27941857 0.83

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101589024-B Minor groove binders UNIV STRATHCLYDE 2014-01-01 CN disclosed
CN-101918368-B Method for improving the hydrolysis stability of ionic liquids BASF SE 2013-04-24 CN disclosed
CN-101918368-A Method for improving the hydrolysis stability of ionic liquids BASF SE 2010-12-15 CN disclosed
CN-101589024-A Novel minor groove binders UNIV STRATHCLYDE (GB) 2009-11-25 CN disclosed