Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.47 |
| ▸ | MTOR | P42345 | 7/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.45 |
| ▸ | ATR | Q13535 | 8/20 | 0.45 |
| ▸ | PDCD1 | Q15116 | 8/20 | 0.45 |
| ▸ | ATRIP | Q8WXE1 | 8/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 8/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27765251 | 0.82 | PIK3CA (0.40) | PIK3CAMTORPIK3CDCHEK1ATR | |
| SCHEMBL3723251 | 0.80 | PDCD1 (0.56) | PIK3CAMTORPIK3CDCHEK1ATR | |
| SCHEMBL3723256 | 0.80 | PDCD1 (0.56) | PIK3CAMTORPIK3CDCHEK1ATR | |
| SCHEMBL3598683 | 0.78 | PIK3CA (0.56) | PIK3CAMTORPIK3CDCHEK1ATR | |
| SCHEMBL27929317 | 0.76 | PIK3CA (0.50) | PIK3CAMTORPIK3CDCHEK1ATR | |
| SCHEMBL3608383 | 0.76 | CHEK1 (0.51) | PIK3CAMTORPIK3CDCHEK1ATR | |
| SCHEMBL3602495 | 0.75 | PIK3CA (0.62) | PIK3CAMTORPIK3CDCHEK1ATR | |
| SCHEMBL27765367 | 0.75 | ATR (0.59) | PIK3CAMTORPIK3CDCHEK1ATR | |
| SCHEMBL739897 | 0.74 | PIK3CA (0.72) | PIK3CAMTORPIK3CDCHEK1ATR | |
| SCHEMBL4358514 | 0.74 | PIK3CA (0.59) | PIK3CAMTORPIK3CDCHEK1ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541781-B | Morpholino pyrimidine derivatives for the treatment of proliferative diseases | ASTRAZENECA AB | 2014-01-08 | — | — | CN | disclosed |
| CN-101541781-A | Morpholino pyrimidine derivatives for the treatment of proliferative diseases | ASTRAZENECA AB (SE) | 2009-09-23 | — | — | CN | disclosed |