Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 8/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 7/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | OXTR | P30559 | 1/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276200 | 0.89 | AGTR1 (0.48) | AGTR1LTB4R2ABCB11GP6CYP2C9 | |
| SCHEMBL2140 | 0.88 | AGTR1 (0.54) | AGTR1LTB4R2ABCB11GP6FFAR1 | |
| SCHEMBL29378073 | 0.88 | AGTR1 (0.54) | AGTR1LTB4R2ABCB11GP6FFAR1 | |
| SCHEMBL1809623 | 0.88 | AGTR1 (0.54) | AGTR1LTB4R2ABCB11GP6FFAR1 | |
| SCHEMBL2780 | 0.86 | FFAR1 (0.35) | AGTR1FFAR1AKR1B1CYP2C9S1PR1 | |
| SCHEMBL2400 | 0.82 | AGTR1 (0.48) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL1975 | 0.82 | AGTR1 (0.48) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL2441623 | 0.82 | AGTR1 (0.47) | AGTR1LTB4R2ABCB11GP6FFAR1 | |
| SCHEMBL8483566 | 0.81 | FFAR1 (0.42) | AGTR1LTB4R2ABCB11GP6FFAR1 | |
| SCHEMBL14032861 | 0.80 | LTB4R2 (0.44) | AGTR1LTB4R2ABCB11GP6FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |