Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 7/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3506811 | 0.82 | EPHX2 (0.39) | PSMB5PPARGEPHX2S1PR4S1PR3 | |
| SCHEMBL3506814 | 0.82 | EPHX2 (0.39) | PSMB5PPARGEPHX2S1PR4S1PR3 | |
| SCHEMBL4382045 | 0.80 | EPHX2 (0.37) | PSMB5PPARGEPHX2S1PR4S1PR3 | |
| SCHEMBL1529843 | 0.78 | EPHX2 (0.38) | PSMB5PPARGEPHX2S1PR4S1PR3 | |
| SCHEMBL1529841 | 0.78 | EPHX2 (0.38) | PSMB5PPARGEPHX2S1PR4S1PR3 | |
| SCHEMBL27770723 | 0.75 | AKT1 (0.46) | PPARGEPHX2LMNAGAAHDAC1 | |
| SCHEMBL27770726 | 0.75 | AKT1 (0.46) | PPARGEPHX2LMNAGAAHDAC1 | |
| SCHEMBL14114930 | 0.66 | ALDH1A1 (0.46) | PPARGEPHX2LMNAGAAPOLB | |
| SCHEMBL27791917 | 0.65 | ALDH1A1 (0.48) | LMNASMN1; SMN2AKT1AKT2AKT3 | |
| SCHEMBL27964015 | 0.64 | PPARG (0.48) | PPARGEPHX2LMNAGAAHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101646427-A | Inhibitors of akt activity | SMITHKLINE BEECHAM CORP US | 2010-02-10 | — | — | CN | disclosed |