Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 10/20 | 0.37 |
| ▸ | PPARG | P37231 | 9/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | CSGALNACT1 | Q8TDX6 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | AKT2 | P31751 | 1/20 | 0.34 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.34 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380618 | 0.83 | ALDH1A1 (0.41) | EPHX2PPARGALDH1A1AKT1AKT2 | |
| SCHEMBL4543975 | 0.81 | NTRK1 (0.34) | EPHX2PPARGMMP1MMP13CSGALNACT1 | |
| SCHEMBL4376050 | 0.80 | AKT1 (0.44) | EPHX2PPARGAKT1AKT2AKT3 | |
| SCHEMBL27791925 | 0.80 | PSMB5 (0.39) | EPHX2PPARGS1PR4S1PR3PSMB5 | |
| SCHEMBL3506811 | 0.80 | EPHX2 (0.39) | EPHX2PPARGS1PR4S1PR3PSMB5 | |
| SCHEMBL3506814 | 0.80 | EPHX2 (0.39) | EPHX2PPARGS1PR4S1PR3PSMB5 | |
| SCHEMBL4439796 | 0.79 | HDAC3 (0.38) | EPHX2PPARGKDM4EALDH1A1HTT | |
| SCHEMBL4379890 | 0.79 | AKT1 (0.43) | EPHX2PPARGAKT1AKT2AKT3 | |
| SCHEMBL1529841 | 0.78 | EPHX2 (0.38) | EPHX2PPARGS1PR4S1PR3PSMB5 | |
| SCHEMBL1529843 | 0.78 | EPHX2 (0.38) | EPHX2PPARGS1PR4S1PR3PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |