Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylamide SCHEMBL27794839 | 0.91 | TSHR (0.42) | TSHRALDH1A1FGFR4CHRM2CHRM4 | |
| Acrylamide SCHEMBL3636541 | 0.90 | TSHR (0.50) | TSHRALDH1A1FGFR4CHRM2CHRM4 | |
| Acrylamide SCHEMBL181865 | 0.90 | POLB (0.36) | TSHRALDH1A1FGFR4BBOX1CHRM2 | |
| Acrylamide SCHEMBL27525225 | 0.89 | TSHR (0.41) | TSHRALDH1A1FGFR4CHRM2CHRM4 | |
| Acrylamide SCHEMBL28403516 | 0.88 | TSHR (0.48) | TSHRALDH1A1FGFR4CHRM2CHRM4 | |
| Acrylamide SCHEMBL134959 | 0.88 | TSHR (0.48) | TSHRALDH1A1FGFR4CHRM2CHRM4 | |
| Acrylamide SCHEMBL28603972 | 0.88 | TSHR (0.48) | TSHRALDH1A1FGFR4CHRM2CHRM4 | |
| Acrylamide SCHEMBL21630022 | 0.88 | TSHR (0.48) | TSHRALDH1A1FGFR4CHRM2CHRM4 | |
| Acrylamide SCHEMBL18550624 | 0.88 | TSHR (0.48) | TSHRALDH1A1FGFR4CHRM2CHRM4 | |
| Acrylamide SCHEMBL28232212 | 0.86 | TSHR (0.46) | TSHRALDH1A1FGFR4CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101672946-B | Polarizer and manufacturing method thereof | SUMITOMO CHEMICAL CO | 2014-07-09 | — | — | CN | disclosed |
| CN-101672946-A | Polarizer and manufacturing method thereof | SUMITOMO CHEMICAL CO | 2010-03-17 | — | — | CN | disclosed |