⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1777396 | 0.90 | — | — | |
| SCHEMBL2251501 | 0.75 | — | — | |
| SCHEMBL11720970 | 0.67 | CRBN (0.50) | — | |
| SCHEMBL22755787 | 0.66 | FKBP5 (0.37) | — | |
| SCHEMBL8096949 | 0.65 | — | — | |
| SCHEMBL1236722 | 0.65 | FKBP5 (0.42) | — | |
| SCHEMBL434844 | 0.63 | — | — | |
| SCHEMBL10070969 | 0.63 | — | — | |
| SCHEMBL22252125 | 0.63 | — | — | |
| SCHEMBL28507164 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056522-A1 | INTRAOCULAR PRESSURE-LOWERING AGENT COMPRISING COMPOUND HAVING HISTONE DEACETYLASE INHIBITOR EFFECT AS ACTIVE INGREDIENT | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2010-03-04 | — | — | US | claimed |
| EP-0002236-A1 | Peptides, their salts, their acid addition salts, pharmaceutical formulations containing them and their use as morphine antagonists and anaesthetics | THE WELLCOME FOUNDATION LIMITED (GB) | 1979-06-13 | — | — | EP | claimed |
| EP-2539317-A2 | DIHYDROLIPOIC ACID DERIVATIVES COMPRISING NITRIC OXIDE AND THERAPEUTIC USES THEREOF | Invasc Therapeutics, Inc. (US) | 2013-01-02 | — | — | EP | disclosed |
| EP-2265611-A1 | TRICYCLIC DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. (IT) | 2010-12-29 | — | — | EP | disclosed |
| WO-2010096677-A2 | DIHYDROLIPOIC ACID DERIVATIVES COMPRISING NITRIC OXIDE AND THERAPEUTIC USES THEREOF | INVASC THERAPEUTICS, INC. (US) | 2010-08-26 | — | — | WO | disclosed |
| WO-2010045575-A2 | COMPOSITIONS AND METHODS FOR TREATMENT OF RENIN-ANGIOTENSIN ALDOSTERONE SYSTEM (RAAS)-RELATED DISORDERS | INVASC THERAPEUTICS, INC. (US) | 2010-04-22 | — | — | WO | disclosed |
| US-20100056522-A1 | INTRAOCULAR PRESSURE-LOWERING AGENT COMPRISING COMPOUND HAVING HISTONE DEACETYLASE INHIBITOR EFFECT AS ACTIVE INGREDIENT | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2010-03-04 | — | — | US | disclosed |
| WO-2009112832-A1 | TRICYCLIC DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2009-09-17 | — | — | WO | disclosed |
| EP-1768955-A1 | AMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2007-04-04 | — | — | EP | disclosed |
| WO-2006005941-A1 | AMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI S.P.A. (IT) | 2006-01-19 | — | — | WO | disclosed |
| US-4363800-A | PEPTIDES USEFUL AS ANTITUSSIVES AND AS ANTI-DIARRHDEALS | BURROUGHS WELLCOME CO. (US) | 1982-12-14 | — | — | US | disclosed |
| US-4362717-A | ANTITUSSIVE AGENTS | BURROUGHS WELLCOME CO. (US) | 1982-12-07 | — | — | US | disclosed |
| US-4346083-A | ANTIDIARRHEAL AND ANTITUSSIVE OLIGOPEPTIDES | BURROUGHS WELLCOME CO. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4343795-A | OLIGOPEPTIDES; ANTIDIARRHEA, ANTITUSSIVE | BURROUGHS WELLCOME CO. (US) | 1982-08-10 | — | — | US | disclosed |
| US-4244944-A | OLIGOPEPTIDE OF TYROSINE, METHIONINE (OPTIONALLY OXIDIZED), GLYCINE, NITROPHENYLALANINE, PROLINAMIDE | BURROUGHS WELLCOME CO. (US) | 1981-01-13 | — | — | US | disclosed |
| EP-0002236-A1 | Peptides, their salts, their acid addition salts, pharmaceutical formulations containing them and their use as morphine antagonists and anaesthetics | THE WELLCOME FOUNDATION LIMITED (GB) | 1979-06-13 | — | — | EP | disclosed |
| US-3988321-A | PREEMERGENCE HERBICIDES | MONSANTO COMPANY (US) | 1976-10-26 | — | — | US | disclosed |
| US-3984383-A | HEAT AGING RESISTANCE, SCORCH RESISTANCE | BRIDGESTONE TIRE COMPANY LIMITED (JA) | 1976-10-05 | — | — | US | disclosed |
| US-3969407-A | Substituted carbamoyl sulfines and their manufacture | MONSANTO COMPANY (US) | 1976-07-13 | — | — | US | disclosed |
| US-3959330-A | HERBICIDE | MONSANTO COMPANY (US) | 1976-05-25 | — | — | US | disclosed |