SCHEMBL27797486

SCHEMBL27797486

COC(=O)c1cccc([N+](=O)[O-])c1CCl

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.57
MAPT P10636 4/20 0.57
MAPK1 P28482 2/20 0.57
KDM4E B2RXH2 3/20 0.56
PKM P14618 1/20 0.56
L3MBTL1 Q9Y468 1/20 0.56
SMN1; SMN2 Q16637 2/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
TSHR P16473 1/20 0.49
LMNA P02545 1/20 0.46
POLB P06746 1/20 0.46
CTSD P07339 1/20 0.45
DHODH Q02127 1/20 0.44
GLA P06280 1/20 0.44
G6PD P11413 1/20 0.44
CRHBP P24387 1/20 0.44
CRHR2 Q13324 1/20 0.44
HPGD P15428 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10192631 0.87 ALDH1A1 (0.58) ALDH1A1MAPTMAPK1KDM4EPKM
SCHEMBL332011 0.85 ALDH1A1 (0.57) ALDH1A1MAPTMAPK1KDM4EPKM
SCHEMBL8113842 0.85 ALDH1A1 (0.57) ALDH1A1MAPTMAPK1KDM4EPKM
SCHEMBL17144681 0.84 ALDH1A1 (0.56) ALDH1A1MAPTMAPK1KDM4EPKM
SCHEMBL10680070 0.83 ALDH1A1 (0.53) ALDH1A1MAPTMAPK1KDM4EPKM
SCHEMBL11048095 0.83 ALDH1A1 (0.55) ALDH1A1MAPTMAPK1KDM4EPKM
SCHEMBL528593 0.83 ALDH1A1 (0.55) ALDH1A1MAPTMAPK1KDM4EPKM
SCHEMBL20916593 0.83 ALDH1A1 (0.55) ALDH1A1MAPTMAPK1KDM4EPKM
SCHEMBL528555 0.83 ALDH1A1 (0.58) ALDH1A1MAPTMAPK1KDM4EPKM
SCHEMBL27862572 0.83 ALDH1A1 (0.55) ALDH1A1MAPTMAPK1KDM4EPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114076801-B Detection method of related substances in lenalidomide 上海博志研新药物研究有限公司 2024-04-02 CN claimed
CN-114076801-A Method for detecting related substances in lenalidomide 上海博志研新药物技术有限公司 2022-02-22 CN claimed
CN-105440014-A Preparation method of lenalidomide HANGZHOU HEZE PHARMACEUTICAL TECH CO LTD 2016-03-30 CN claimed
CN-101665484-B Method for preparing lenalidomide SHANGHAI HAOYUAN CHEMEXPRESS BIO PHARMACEUTICAL TECHNOLOGY CO LTD 2012-11-21 CN claimed
CN-101665484-A Method for preparing lenalidomide SHANGHAI HAOYUAN CHEMEXPRESS B 2010-03-10 CN claimed
CN-114076801-B Detection method of related substances in lenalidomide 上海博志研新药物研究有限公司 2024-04-02 CN disclosed
CN-114076801-A Method for detecting related substances in lenalidomide 上海博志研新药物技术有限公司 2022-02-22 CN disclosed
CN-109608434-B Preparation method of lenalidomide 浙江工业大学 2020-10-02 CN disclosed
CN-105440014-A Preparation method of lenalidomide HANGZHOU HEZE PHARMACEUTICAL TECH CO LTD 2016-03-30 CN disclosed
CN-103554082-B A kind of synthesis 3-(4-amino-1-isoindolone-2-base) method of piperidines-2,6-diketone NANJING OCEAN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) 2015-12-02 CN disclosed
CN-103554082-B A kind of synthesis 3-(4-amino-1-isoindolone-2-base) method of piperidines-2,6-diketone NANJING OCEAN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) 2015-12-02 CN disclosed
CN-101665484-B Method for preparing lenalidomide SHANGHAI HAOYUAN CHEMEXPRESS BIO PHARMACEUTICAL TECHNOLOGY CO LTD 2012-11-21 CN disclosed
CN-101665484-A Method for preparing lenalidomide SHANGHAI HAOYUAN CHEMEXPRESS B 2010-03-10 CN disclosed