Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528555 | 0.92 | ALDH1A1 (0.58) | ALDH1A1MAPTMAPK1KDM4EPKM | |
| SCHEMBL332011 | 0.89 | ALDH1A1 (0.57) | ALDH1A1MAPTMAPK1KDM4EPKM | |
| SCHEMBL27431445 | 0.86 | ALDH1A1 (0.55) | ALDH1A1MAPTMAPK1KDM4EPKM | |
| SCHEMBL10192631 | 0.84 | ALDH1A1 (0.58) | ALDH1A1MAPTMAPK1KDM4EPKM | |
| SCHEMBL8113842 | 0.83 | ALDH1A1 (0.57) | ALDH1A1MAPTMAPK1KDM4EPKM | |
| SCHEMBL27797486 | 0.83 | ALDH1A1 (0.57) | ALDH1A1MAPTMAPK1KDM4EPKM | |
| SCHEMBL17144681 | 0.82 | ALDH1A1 (0.56) | ALDH1A1MAPTMAPK1KDM4EPKM | |
| SCHEMBL11048095 | 0.81 | ALDH1A1 (0.55) | ALDH1A1MAPTMAPK1KDM4EPKM | |
| SCHEMBL20916593 | 0.81 | ALDH1A1 (0.55) | ALDH1A1MAPTMAPK1KDM4EPKM | |
| SCHEMBL27862572 | 0.81 | ALDH1A1 (0.55) | ALDH1A1MAPTMAPK1KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150336927-A1 | SUBSTITUTED DIOXOPIPERIDINYL PHTHALIMIDE DERIVATIVES | CONCERT PHARMACEUTICALS, INC. | 2015-11-26 | — | — | US | disclosed |
| US-9045453-B2 | Substituted dioxopiperidinyl phthalimide derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2015-06-02 | — | — | US | disclosed |
| WO-2014110322-A2 | SUBSTITUTED DIOXOPIPERIDINYL PHTHALIMIDE DERIVATIVES | CONCERT PHARMACEUTICALS, INC. (US) | 2014-07-17 | — | — | WO | disclosed |
| EP-2373165-B1 | SUBSTITUTED DIOXOPIPERIDINYL PHTHALIMIDE DERIVATIES | CONCERT PHARMACEUTICALS INC (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012015986-A2 | SUBSTITUTED DIOXOPIPERIDINYL PHTALIMIDE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2012-02-02 | — | — | WO | disclosed |
| US-20110288126-A1 | SUBSTITUTED DIOXOPIPERIDINYL PHTHALIMIDE DERIVATIVES | CONCERT PHARMACEUTICALS, INC. (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110288126-A1 | SUBSTITUTED DIOXOPIPERIDINYL PHTHALIMIDE DERIVATIVES | CONCERT PHARMACEUTICALS, INC. (US) | 2011-11-24 | — | — | US | disclosed |
| EP-2373165-A1 | SUBSTITUTED DIOXOPIPERIDINYL PHTHALIMIDE DERIVATIES | CONCERT PHARMACEUTICALS, INC. (US) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010056344-A1 | SUBSTITUTED DIOXOPIPERIDINYL PHTHALIMIDE DERIVATIES | CONCERT PHARMACEUTICALS INC. (US) | 2010-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288126-A1 | SUBSTITUTED DIOXOPIPERIDINYL PHTHALIMIDE DERIVATIVES | NFATC1, PDCD11, IL5 | ALDH1A1 1306/4885MAPT 863/4885MAPK1 3843/4885 |
| US-20150336927-A1 | SUBSTITUTED DIOXOPIPERIDINYL PHTHALIMIDE DERIVATIVES | NFATC1, PDCD11, IL5 | ALDH1A1 1306/4885MAPT 863/4885MAPK1 3843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.