Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | BLM | P54132 | 2/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.55 |
| ▸ | MPO | P05164 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 11/20 | 0.42 |
| ▸ | BCHE | P06276 | 10/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | NLN | Q9BYT8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL4772234 | 1.00 | KMT2A (0.55) | KMT2AKDM4EMAPTMEN1LMNA | |
| Tryptophan SCHEMBL4772236 | 1.00 | KMT2A (0.55) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL28798128 | 0.95 | KDM4E (0.50) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL4777903 | 0.94 | KDM4E (0.49) | KMT2AKDM4EMAPTMEN1LMNA | |
| Tryptophan SCHEMBL4777905 | 0.94 | KDM4E (0.49) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL28861104 | 0.94 | MEN1 (0.48) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL27361088 | 0.93 | KDM4E (0.48) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL1533586 | 0.90 | KDM4E (0.68) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL28512622 | 0.90 | KDM4E (0.68) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL28518234 | 0.90 | KDM4E (0.68) | KMT2AKDM4EMAPTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8741843-B2 | Compositions and methods for inducing angiogenesis | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2014-06-03 | — | — | US | disclosed |
| US-20120219498-A1 | COMPOSITIONS AND METHODS FOR INDUCING ANGIOGENESIS | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2012-08-30 | — | — | US | disclosed |
| US-8227413-B2 | Compositions and methods for inducing angiogenesis | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2012-07-24 | — | — | US | disclosed |
| US-20100322856-A1 | Compositions and Methods for Inducing Angiogenesis | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2010-12-23 | — | — | US | disclosed |
| WO-2010052715-A2 | DEVICES AND METHODS FOR LOCAL TREATMENT OF CARDIOVASCULAR DISEASES | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2010-05-14 | — | — | WO | disclosed |
| EP-2106404-A2 | COMPOSITIONS AND METHODS FOR INDUCING ANGIOGENESIS | Ramot at Tel Aviv University Ltd. (IL) | 2009-10-07 | — | — | EP | disclosed |
| WO-2008047370-A2 | COMPOSITIONS AND METHODS FOR INDUCING ANGIOGENESIS | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2008-04-24 | — | — | WO | disclosed |