Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | MC4R | P32245 | 2/20 | 0.45 |
| ▸ | MC5R | P33032 | 1/20 | 0.45 |
| ▸ | MC3R | P41968 | 1/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.45 |
| ▸ | TUBB | P07437 | 1/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL27971563 | 0.96 | TUBB4A (0.49) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL28861104 | 0.95 | MEN1 (0.48) | KDM4EMEN1LMNAMPOMAPT | |
| Tryptophan SCHEMBL4772236 | 0.93 | KMT2A (0.55) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL4772234 | 0.93 | KMT2A (0.55) | KDM4EMEN1LMNAMPOMAPT | |
| Tryptophan SCHEMBL2779783 | 0.93 | KMT2A (0.55) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL27780062 | 0.92 | TUBB4A (0.48) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Dl-Tryptophan SCHEMBL27458897 | 0.92 | TUBB4A (0.48) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Dl-Tryptophan SCHEMBL27709285 | 0.91 | KDM4E (0.57) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL28366886 | 0.91 | KDM4E (0.57) | KDM4EMEN1LMNAMPOMAPT | |
| Tryptophan SCHEMBL27641188 | 0.91 | KDM4E (0.57) | KDM4EMEN1LMNAMPOMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1089454-A | Black polished glutinous rice beverage and production method thereof | YANCHENG CHARACTERISTIC AGRICU (CN) | 1994-07-20 | — | — | CN | disclosed |
| CN-1070827-A | Up-to-date therapeutic agent of diabetes and method for making thereof | HOSPITAL JINAN CITY CENTRE (CN) | 1993-04-14 | — | — | CN | disclosed |