Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | MMP8 | P22894 | 3/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | ECE1 | P42892 | 5/20 | 0.42 |
| ▸ | ERAP2 | Q6P179 | 6/20 | 0.42 |
| ▸ | ERAP1 | Q9NZ08 | 5/20 | 0.42 |
| ▸ | ANPEP | P15144 | 4/20 | 0.42 |
| ▸ | IL1RN | P18510 | 3/20 | 0.41 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL4777903 | 1.00 | KDM4E (0.49) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL2779783 | 0.94 | KMT2A (0.55) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL4772236 | 0.94 | KMT2A (0.55) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL4772234 | 0.94 | KMT2A (0.55) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL28764380 | 0.93 | KDM4E (0.42) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL27780062 | 0.91 | TUBB4A (0.48) | KISS1R | |
| Dl-Tryptophan SCHEMBL27458897 | 0.90 | TUBB4A (0.48) | KISS1R | |
| Dl-Tryptophan SCHEMBL28798128 | 0.90 | KDM4E (0.50) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL28861104 | 0.89 | MEN1 (0.48) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL28338052 | 0.88 | KDM4E (0.55) | KDM4EMAPTMEN1LMNAMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799261-A4 | METHODS AND COMPOSITIONS FOR COMBINATORAL-BASED PRODUCTION OF MULTIVALENT RECOMBINANT ANTIGENS | NEUGENESIS CORP (US) | 2008-09-03 | — | — | EP | disclosed |
| EP-1799261-A2 | METHODS AND COMPOSITIONS FOR COMBINATORAL-BASED PRODUCTION OF MULTIVALENT RECOMBINANT ANTIGENS | Neugenesis Corporation (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006044796-A2 | METHODS AND COMPOSITIONS FOR COMBINATORAL-BASED PRODUCTION OF MULTIVALENT RECOMBINANT ANTIGENS | NEUGENESIS CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |