Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 14/20 | 0.64 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.54 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.54 |
| ▸ | KIF11 | P52732 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28875440 | 0.89 | KCNN4 (0.72) | KCNN4KCNE1KCNQ1KIF11MAPT | |
| SCHEMBL6688626 | 0.89 | MAPT (0.52) | KCNN4KCNE1KCNQ1MAPTKMT2A | |
| SCHEMBL16892955 | 0.81 | KCNN4 (0.68) | KCNN4KCNE1KCNQ1MAPTKMT2A | |
| Senicapoc SCHEMBL1443805 | 0.78 | KCNN4 (1.00) | KCNN4KCNE1KCNQ1KIF11MAPT | |
| SCHEMBL2337394 | 0.78 | KCNN4 (1.00) | KCNN4KCNE1KCNQ1KIF11MAPT | |
| SCHEMBL830791 | 0.77 | MAPT (0.60) | KCNN4KCNE1KCNQ1MAPTKMT2A | |
| SCHEMBL6832584 | 0.77 | KCNN4 (0.43) | KCNN4MAPTKMT2A | |
| SCHEMBL28151671 | 0.75 | KCNN4 (0.68) | KCNN4KCNE1KCNQ1KIF11MAPT | |
| SCHEMBL5056595 | 0.75 | KCNN4 (0.68) | KCNN4KCNE1KCNQ1KIF11MAPT | |
| SCHEMBL12811863 | 0.72 | KCNN4 (0.86) | KCNN4KCNE1KCNQ1KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102947315-A | Inhibitors of protein tyrosine kinase activity | METHYLGENE INC | 2013-02-27 | — | — | CN | disclosed |
| CN-101932586-A | Inhibition of protein tyrosine kinase activity | METHYLGENE INC | 2010-12-29 | — | — | CN | disclosed |