Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNE | Q04844 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27804109 | 0.85 | NOTUM (0.48) | CHRNEMAPK1KMT2AHDAC1NOTUM | |
| SCHEMBL4285071 | 0.84 | MAPK1 (0.34) | CHRNEHSP90AB1MAPK1KMT2AHDAC1 | |
| SCHEMBL2176041 | 0.75 | ALDH1A1 (0.50) | MAPK1KMT2A | |
| Hydrochloric Acid SCHEMBL5913639 | 0.74 | ALDH1A1 (0.48) | MAPK1KMT2A | |
| SCHEMBL3399659 | 0.70 | MAPT (0.44) | MAPK1KMT2A | |
| SCHEMBL15425743 | 0.69 | CYP19A1 (0.67) | HSP90AB1CYP19A1 | |
| SCHEMBL12432223 | 0.67 | NOTUM (0.42) | HSP90AB1NOTUMCYP19A1 | |
| SCHEMBL4294198 | 0.67 | KMT2A (0.43) | MAPK1KMT2AHDAC1 | |
| SCHEMBL16198599 | 0.67 | HDAC1 (0.51) | HSP90AB1HDAC1CYP19A1 | |
| SCHEMBL1674266 | 0.66 | NOTUM (0.61) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101981036-B | Pyrrolo [2, 3-D] pyridines and use thereof as tyrosine kinase inhibitors | NOVARTIS AG | 2013-09-04 | — | — | CN | disclosed |
| CN-101981036-A | Pyrrolo [2, 3-D] pyridines and use thereof as tyrosine kinase inhibitors | NOVARTIS AG | 2011-02-23 | — | — | CN | disclosed |