Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.43 |
| ▸ | BTK | Q06187 | 4/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | BCR | P11274 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.34 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.33 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3646314 | 0.87 | EGFR (0.44) | EGFRBTKCCNT1CCNE1CDK2 | |
| SCHEMBL3653338 | 0.85 | EGFR (0.44) | EGFRBTKCCNT1CCNE1CDK2 | |
| SCHEMBL27785685 | 0.74 | EGFR (0.46) | EGFRBTKCCNT1CCNE1CDK2 | |
| SCHEMBL3643667 | 0.71 | ABL1 (0.41) | EGFRBTKCDK2ABL1BCR | |
| Tert-Butyl Formate SCHEMBL27789630 | 0.70 | CCNC (0.44) | EGFRBTK | |
| SCHEMBL1735407 | 0.69 | CCNT1 (0.48) | CCNT1CCNE1CDK2CDK9ABL1 | |
| SCHEMBL1734419 | 0.69 | L3MBTL3 (0.53) | ABL1BCR | |
| SCHEMBL13605609 | 0.69 | LRRK2 (0.48) | ABL1BCR | |
| SCHEMBL13605579 | 0.68 | KMT2A (0.52) | ABL1BCRNTRK1NTRK3NTRK2 | |
| SCHEMBL1735254 | 0.68 | L3MBTL3 (0.52) | ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101784530-A | 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC | 2010-07-21 | — | — | CN | claimed |
| CN-101784530-A | 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC | 2010-07-21 | — | — | CN | disclosed |