Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.46 |
| ▸ | BTK | Q06187 | 4/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | CCNK | O75909 | 2/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | CCNH | P51946 | 1/20 | 0.36 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3646314 | 0.83 | EGFR (0.44) | EGFRBTKNTRK1KDM4ERECQL | |
| SCHEMBL27785690 | 0.76 | EGFR (0.42) | EGFRBTKNTRK1CDK2CCNK | |
| SCHEMBL27785691 | 0.74 | EGFR (0.40) | EGFRBTKNTRK1CDK2CCNK | |
| SCHEMBL27807592 | 0.74 | EGFR (0.43) | EGFRBTKNTRK1KDM4ERECQL | |
| SCHEMBL3651442 | 0.74 | EGFR (0.42) | EGFRBTKNTRK1 | |
| SCHEMBL2328664 | 0.73 | CCNC (0.48) | EGFRBTK | |
| SCHEMBL27785692 | 0.73 | EGFR (0.40) | EGFRBTKCDK2CCNKCDK12 | |
| SCHEMBL1735157 | 0.72 | CCNC (0.55) | NTRK1 | |
| SCHEMBL28775729 | 0.72 | CCNK (0.52) | EGFRBTKNTRK1CDK2CCNK | |
| SCHEMBL13472152 | 0.72 | GRM5 (0.42) | EGFRBTKCDK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101784530-A | 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC | 2010-07-21 | — | — | CN | claimed |
| CN-101784530-A | 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC | 2010-07-21 | — | — | CN | disclosed |