Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 8/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | UGCG | Q16739 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.31 |
| ▸ | CDK9 | P50750 | 3/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27807957 | 0.88 | GABRG2 (0.36) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27786017 | 0.87 | ALK (0.35) | GABRG2GABRB3GABRA2CNR2UGCG | |
| SCHEMBL27807919 | 0.87 | GABRG2 (0.33) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27807932 | 0.86 | GABRG2 (0.41) | GABRG2GABRB3GABRA2UGCGGRIN2B | |
| SCHEMBL27785971 | 0.86 | GABRG2 (0.33) | GABRG2GABRB3GABRA2ROCK2 | |
| SCHEMBL27807949 | 0.86 | GABRG2 (0.35) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27786174 | 0.85 | GABRG2 (0.50) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27785925 | 0.85 | GABRA2 (0.36) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27807990 | 0.84 | GABRG2 (0.35) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27786205 | 0.84 | GABRG2 (0.34) | GABRG2GABRB3GABRA2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | claimed |
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |