Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 9/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | FPR1 | P21462 | 1/20 | 0.30 |
| ▸ | FPR2 | P25090 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | BRD2 | P25440 | 1/20 | 0.30 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27807963 | 0.87 | GABRG2 (0.50) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27785960 | 0.87 | PIK3CA (0.35) | GABRG2GABRB3GABRA2PIK3CAGABRA5 | |
| SCHEMBL27807951 | 0.87 | GABRG2 (0.37) | GABRG2GABRB3GABRA2ALOX5APFEN1 | |
| SCHEMBL27807926 | 0.86 | ALDH1A1 (0.31) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27808006 | 0.85 | PIK3CA (0.37) | GABRG2GABRB3GABRA2ALOX5APFEN1 | |
| SCHEMBL27807958 | 0.83 | GABRG2 (0.36) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL28784319 | 0.83 | GABRG2 (0.39) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27807932 | 0.82 | GABRG2 (0.41) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL28787439 | 0.82 | GABRG2 (0.36) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27786050 | 0.81 | GABRG2 (0.35) | GABRG2GABRB3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |