Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 2/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27785990 | 0.98 | HRH4 (0.32) | HRH4ACHECHRNB2CHRNA4ADORA1 | |
| SCHEMBL27786083 | 0.96 | CHRNB2 (0.34) | HRH4ACHECHRNB2CHRNA4ADORA1 | |
| SCHEMBL27786086 | 0.87 | HRH4 (0.35) | HRH4ACHECHRNB2CHRNA4 | |
| SCHEMBL27785937 | 0.83 | ADORA2A (0.32) | ADORA1 | |
| SCHEMBL27807960 | 0.82 | ADORA2A (0.35) | ACHECHRNB2CHRNA4ADORA1 | |
| SCHEMBL27807945 | 0.82 | HRH4 (0.39) | HRH4ACHEADORA1 | |
| SCHEMBL27807943 | 0.80 | — | — | |
| SCHEMBL27786093 | 0.80 | LCK (0.30) | — | |
| SCHEMBL27807956 | 0.79 | HRH4 (0.35) | HRH4ADORA1 | |
| SCHEMBL27807959 | 0.79 | HRH4 (0.35) | HRH4ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |