Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27785935 | 0.96 | MAPK1 (0.31) | ADORA2AADORA1 | |
| SCHEMBL27807943 | 0.88 | — | — | |
| SCHEMBL27807960 | 0.87 | ADORA2A (0.35) | ADORA2AADORA1ADRA1AKCNH2HRH3 | |
| SCHEMBL27785941 | 0.86 | — | — | |
| SCHEMBL27786079 | 0.83 | MEN1 (0.32) | — | |
| SCHEMBL27807950 | 0.83 | HRH4 (0.32) | ADORA1 | |
| SCHEMBL27785985 | 0.82 | CRHR1 (0.30) | — | |
| SCHEMBL27786093 | 0.82 | LCK (0.30) | — | |
| SCHEMBL27785931 | 0.82 | — | — | |
| SCHEMBL28787383 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | claimed |
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |