Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | SSTR2 | P30874 | 5/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.32 |
| ▸ | BACE1 | P56817 | 2/20 | 0.32 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27785978 | 0.89 | SSTR2 (0.33) | HRH4SSTR2PIK3CDBTKLRRK2 | |
| SCHEMBL27807955 | 0.89 | SSTR2 (0.33) | HRH4SSTR2PIK3CDBTKLRRK2 | |
| SCHEMBL28784318 | 0.89 | SSTR2 (0.35) | HRH4SSTR2PIK3CDBTKLRRK2 | |
| SCHEMBL28784320 | 0.88 | GABRG2 (0.33) | HRH4SSTR2LRRK2GABRG2GABRB3 | |
| SCHEMBL27785963 | 0.87 | SSTR2 (0.34) | HRH4SSTR2PIK3CDBTKLRRK2 | |
| SCHEMBL27785945 | 0.87 | PIK3CA (0.35) | HRH4SSTR2PIK3CDBTKLRRK2 | |
| SCHEMBL27786006 | 0.86 | GABRG2 (0.33) | HRH4SSTR2LRRK2GABRG2GABRB3 | |
| SCHEMBL27807969 | 0.86 | HRH4 (0.34) | HRH4SSTR2LRRK2ENPP1BACE1 | |
| SCHEMBL27786064 | 0.86 | GABRG2 (0.34) | PIK3CDBTKBACE1GABRG2GABRB3 | |
| SCHEMBL27807907 | 0.83 | ALK (0.35) | GABRG2GABRB3GABRA2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |