Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | UGCG | Q16739 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27807995 | 0.89 | GABRG2 (0.34) | ALKGABRG2GABRB3GABRA2ADORA2A | |
| SCHEMBL27786017 | 0.89 | ALK (0.35) | ALKGABRG2GABRB3GABRA2ADORA2A | |
| SCHEMBL27807933 | 0.86 | GABRA1 (0.45) | GABRG2GABRB3GABRA2ADORA2AGABRA1 | |
| SCHEMBL27807927 | 0.84 | GABRG2 (0.32) | GABRG2GABRB3GABRA2ADORA2AGABRA1 | |
| SCHEMBL27807964 | 0.83 | HRH4 (0.35) | GABRG2GABRB3GABRA2KCNH2 | |
| SCHEMBL27807917 | 0.80 | GABRG2 (0.36) | GABRG2GABRB3GABRA2ADORA2AGABRA1 | |
| SCHEMBL27785951 | 0.78 | CRHR1 (0.41) | GABRG2GABRB3GABRA2CCNT1CDK9 | |
| SCHEMBL27807918 | 0.76 | LCK (0.47) | — | |
| SCHEMBL27807932 | 0.76 | GABRG2 (0.41) | GABRG2GABRB3GABRA2KCNH2CCNT1 | |
| SCHEMBL27807945 | 0.75 | HRH4 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | claimed |
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |