Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR1 | P24046 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.32 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.32 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16574791 | 0.88 | BLM (0.47) | GABRR1CYP1A2BLMACE2LTA4H | |
| SCHEMBL16574757 | 0.86 | LTA4H (0.46) | GABRR1CYP1A2BLMACE2LTA4H | |
| SCHEMBL16920503 | 0.86 | LTA4H (0.46) | GABRR1CYP1A2BLMACE2LTA4H | |
| SCHEMBL14704268 | 0.80 | — | — | |
| SCHEMBL17193565 | 0.80 | — | — | |
| SCHEMBL15317631 | 0.80 | — | — | |
| SCHEMBL17311980 | 0.76 | TET2 (0.44) | — | |
| SCHEMBL13873420 | 0.76 | TET2 (0.44) | — | |
| SCHEMBL5139179 | 0.75 | GABRR1 (0.72) | GABRR1CYP1A2BLMACE2LTA4H | |
| SCHEMBL19435711 | 0.75 | CA2 (0.50) | CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101754970-B | Macrocyclic indole derivatives for the treatment of hepatitis c infections | ANGELETTI P IST RICHERCHE BIO | 2013-07-10 | — | — | CN | disclosed |
| CN-101801982-A | Macrocyclic indole derivatives for the treatment of hepatitis C infections | ANGELETTI P IST RICHERCHE BIO | 2010-08-11 | — | — | CN | disclosed |
| CN-101754970-A | The Macrocyclic indole derivatives that is used for the treatment of hepatitis C | ANGELETTI P IST RICHERCHE BIO | 2010-06-23 | — | — | CN | disclosed |