Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 6/20 | 0.59 |
| ▸ | PDE4A | P27815 | 14/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL309040 | 0.89 | TPH1 (0.60) | TPH1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27809367 | 0.89 | TPH1 (0.58) | TPH1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL309041 | 0.89 | TPH1 (0.60) | TPH1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27829761 | 0.88 | TPH1 (0.58) | TPH1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL307423 | 0.81 | TPH1 (0.81) | TPH1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL307424 | 0.81 | TPH1 (0.81) | TPH1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27809373 | 0.78 | TPH1 (0.66) | TPH1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL308640 | 0.77 | TPH1 (0.61) | TPH1 | |
| SCHEMBL2303806 | 0.77 | TPH1 (0.61) | TPH1 | |
| SCHEMBL308165 | 0.77 | TPH1 (0.61) | TPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102753168-A | Tryptophan hydroxylase inhibitors for the treatment of metastatic bone disease | LEXICON PHARMACEUTICALS INC | 2012-10-24 | — | — | CN | disclosed |
| CN-102083454-A | Methods for diagnosing, preventing and treating bone mass disorders | UNIV COLUMBIA | 2011-06-01 | — | — | CN | disclosed |