Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.55 |
| ▸ | REN | P00797 | 1/20 | 0.54 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.53 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.53 |
| ▸ | PREP | P48147 | 2/20 | 0.53 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.51 |
| ▸ | ELANE | P08246 | 1/20 | 0.51 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.49 |
| ▸ | CMA1 | P23946 | 3/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2248715 | 0.98 | ACE (0.53) | ACERENRAMP1CALCRLPREP | |
| SCHEMBL2248710 | 0.98 | ACE (0.53) | ACERENRAMP1CALCRLPREP | |
| Carbon Dioxide SCHEMBL2250507 | 0.98 | PREP (0.53) | ACERENRAMP1CALCRLPREP | |
| SCHEMBL2252316 | 0.94 | REN (0.49) | ACERENRAMP1CALCRLPREP | |
| SCHEMBL2252313 | 0.94 | REN (0.49) | ACERENRAMP1CALCRLPREP | |
| SCHEMBL13706598 | 0.93 | ACE (0.53) | ACERENRAMP1CALCRLPREP | |
| SCHEMBL27809460 | 0.92 | ACE (0.57) | ACERAMP1CALCRLPREPCTRB1 | |
| SCHEMBL8259265 | 0.90 | ACE (0.51) | ACERENRAMP1CALCRLPREP | |
| Carbon Dioxide SCHEMBL2247895 | 0.90 | PREP (0.55) | ACERAMP1CALCRLPREPCTRB1 | |
| SCHEMBL2249471 | 0.90 | ACE (0.55) | ACERAMP1CALCRLPREPCTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102083499-B | II type anti-CD 20 antibodies and the conjoint therapy of proteasome inhibitor | ROCHE GLYCART AG (CH) | 2016-12-14 | — | — | CN | disclosed |
| CN-102083499-A | Combination therapy of a type II anti-CD20 antibody with a proteasome inhibitor | HOFFMANN LA ROCHE | 2011-06-01 | — | — | CN | disclosed |