Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27787521 | 0.89 | TRPV1 (0.39) | TRPV1ALDH1A1SMN1; SMN2MAPTSIRT2 | |
| SCHEMBL27809610 | 0.87 | TRPV1 (0.41) | TRPV1ALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL28784442 | 0.86 | ALDH1A1 (0.40) | TRPV1ALDH1A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL27787525 | 0.86 | NOTUM (0.36) | ALDH1A1SMN1; SMN2MAPTPOLBNOTUM | |
| SCHEMBL27809486 | 0.84 | FFAR4 (0.40) | ALDH1A1SMN1; SMN2MAPTPOLBKDM4E | |
| SCHEMBL27787498 | 0.84 | TRPV1 (0.44) | TRPV1SIRT2MEN1KMT2A | |
| SCHEMBL5447673 | 0.77 | NOTUM (0.49) | TRPV1ALDH1A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL27809613 | 0.76 | MEN1 (0.39) | TRPV1ALDH1A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL28784443 | 0.73 | TRPV1 (0.51) | TRPV1 | |
| SCHEMBL27787523 | 0.73 | TRPV1 (0.41) | TRPV1ALDH1A1SMN1; SMN2MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101796036-A | 5-Phenylisoxazole-3-carboxamide derivatives as TRPV1 modulators | ORGANON NV | 2010-08-04 | — | — | CN | disclosed |