Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | AR | P10275 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | EIF4E | P06730 | 1/20 | 0.45 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL973461 | 0.83 | ALDH1A1 (0.53) | HPGDRAB9AALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL16208120 | 0.76 | HPGD (0.45) | HPGDRAB9AALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL1473981 | 0.70 | AR (0.71) | HPGDRAB9AALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL8150805 | 0.69 | HPGD (0.76) | HPGDRAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL18029576 | 0.69 | NPC1 (0.59) | HPGDRAB9ASMN1; SMN2LMNAMAPK1 | |
| SCHEMBL29427783 | 0.69 | NPC1 (0.59) | HPGDRAB9ASMN1; SMN2LMNAMAPK1 | |
| SCHEMBL3664800 | 0.68 | HSD11B1 (0.56) | RAB9AALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL2553916 | 0.68 | SMN1; SMN2 (0.74) | HPGDRAB9AALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL6102102 | 0.68 | HPGD (0.57) | HPGDATRMKNK1MKNK2TSHR | |
| SCHEMBL5767357 | 0.67 | HPGD (0.57) | HPGDRAB9AALDH1A1HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101981026-A | Tetrahydroquinoxaline urea derivatives, their preparation and their therapeutic use | SANOFI AVENTIS | 2011-02-23 | — | — | CN | disclosed |