Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | DGKA | P23743 | 2/20 | 0.32 |
| ▸ | DGKZ | Q13574 | 2/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.31 |
| ▸ | TYMS | P04818 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.30 |
| ▸ | STAT3 | P40763 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27733525 | 0.87 | GRM2 (0.57) | GRM2PPARGPPARDPPARATSHR | |
| SCHEMBL2024656 | 0.80 | GRM2 (0.73) | GRM2PPARGPPARDPPARATSHR | |
| SCHEMBL27905983 | 0.79 | ALDH1A1 (0.34) | GRM2TSHRDGKADGKZHCRTR1 | |
| SCHEMBL27703741 | 0.78 | LSS (0.42) | GRM2TSHRHCRTR1ALDH1A1SLC6A4 | |
| SCHEMBL27684910 | 0.77 | ALDH1A1 (0.40) | GRM2TSHRHCRTR1ALDH1A1 | |
| SCHEMBL27704001 | 0.77 | GRM2 (0.40) | GRM2HCRTR1CYP3A4ALDH1A1 | |
| SCHEMBL27684948 | 0.76 | LSS (0.43) | GRM2TSHRHCRTR1ALDH1A1SLC6A4 | |
| SCHEMBL27703939 | 0.76 | ABL1 (0.40) | GRM2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL27684946 | 0.76 | HCRTR1 (0.42) | GRM2TSHRHCRTR1ALDH1A1 | |
| SCHEMBL27704258 | 0.75 | ALDH1A1 (0.40) | GRM2TSHRHCRTR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101039907-B | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB | 2011-02-23 | — | — | CN | disclosed |