Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 11/20 | 0.57 |
| ▸ | PSEN2 | P49810 | 11/20 | 0.57 |
| ▸ | APH1B | Q8WW43 | 11/20 | 0.57 |
| ▸ | NCSTN | Q92542 | 11/20 | 0.57 |
| ▸ | APH1A | Q96BI3 | 11/20 | 0.57 |
| ▸ | PSENEN | Q9NZ42 | 11/20 | 0.57 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.49 |
| ▸ | WNT3A | P56704 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27809664 | 0.84 | GRM4 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27830111 | 0.84 | PSEN1 (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492788 | 0.82 | HTR2C (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492785 | 0.82 | PSEN1 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492989 | 0.80 | SMN1; SMN2 (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492820 | 0.79 | MAPT (0.65) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492843 | 0.78 | NPC1 (0.64) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492969 | 0.78 | PSEN1 (0.67) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492687 | 0.78 | PORCN (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492881 | 0.77 | PSEN1 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102083794-A | Urea compounds as gamma secretase modulators | AMGEN INC | 2011-06-01 | — | — | CN | claimed |